Akademik Kadro

Prof. Dr. Fatma Neşe Kök

Akademik dereceler ve çalışma deneyimi

Prof. Dr. (2019-   ) – İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü

Doç. Dr. (2012-2019) – İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü

Y. Doç. Dr. (2005-2012) – İstanbul Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul

Doktora Sonrası Araştırmacı (2003-2005)- Max Planck Institute for Polymer Research, Germany; Max Planck Institute for Biochemistry, Almanya

Doktora Sonrası Araştırmacı (2001-2003)- O.D.T.Ü. Fen Bilimleri Enstitüsü, Ankara

Araştırma görevlisi (1996-2001) – O.D.T.Ü. Biyoteknoloji Bölümü, Ankara

Doktora (1997-2001) – Biyoteknoloji Bölümü, O.D.T.Ü., Ankara

Yüksek Lisans (1995-1997) – Biyoteknoloji Bölümü, O.D.T.Ü., Ankara

Lisans (1990-1994) – Kimya Mühendisliği Bölümü, O.D.T.Ü., Ankara

İlgi alanları

• Biyomoleküllerin ve biyoaktif ajanların immobilizasyonu: Oligonükleotid, antikor, enzim gibi biyomoleküllerin biyoteknolojik uygulamalar için immobilizasyonu: Biyosensörler, biyomimetik/biyouyumlu yüzeyler, biyoreaktörler, vb alanlarında kullanımları
• Biyoaktif moleküllerin enkapsülasyonu ve kontrollü salımı: İlaç, pestisit, aroma, hücre gibi birçok malzemenin gıda, çevre, tıp uygulamaları için enkasülasyonu ve/ve ya kontrollü salımı
• Biyomalzemeler ve Doku Mühendisliği: Polimerik yapı iskeleleri oluşturulması, modifikasyonu, kimyasal ve biyolojik karakterizasyonları, metal ve polimer tabanlı implantlar
• Yapay lipid zarlar: Hücre zarı hakkında bilgi edinmek ve membran proteinleri ile çalışmak için yapay lipid zarlar oluşturulması; Yüzey Plazmon Rezonans (SPR) ve Kuvars Kristal Mikroterazi (QCM) gibi yöntemlerle karakterizasyon

Yayınlar

1. A.Kılıç, F.N.Kök, Quartz crystal microbalance with dissipation as a biosensing platform to evaluate cell–surface interactions of osteoblast cells, Biointerphases 13, 011001 (2018)
2. Z.Guler-Gokce, P.Akalın , F.N.Kok, A.S.Sarac, Impedimetric DNA biosensor based on Polyurethane/Poly(m-anthranilic acid) Nanofibers, Sensors & Actuators: B. Chemical, 254C (2018) pp. 719-726, 10.1016/j.snb.2017.07.136 http://www.sciencedirect.com/science/article/pii/S0925400517313515
3. A.Kılıç, M.F. Jadidi, H.Ö.Özer, F.N.Kök, The effect of thiolated phospholipids on formation of supported lipid bilayers on gold substrates investigated by surface-sensitive methods, Colloids and Surfaces B: Biointerfaces, 160 (2017) 117-125
4. G.G.Pekozer,M. Ramazanoglu, K.A.Schlegel, F.N.Kok and G.T.Kose, Role of STRO-1 sorting of porcine dental germ stem cells in dental stem cell-mediated bone tissue engineering, Artificial Cells, Nanomedicine, and Biotechnology, 2017, doi 10.1080/21691401.2017.1332637
5. Ertan A.B., Kenar H., Beyzadeoglu T., F.N.Kok , Kose G.T., An in vitro human skeletal muscle model: coculture of myotubes, neuron-like cells, and the capillary network, Turk J Biol (2017) 41: doi:10.3906/biy-1611-22
6. A. Kilic, F.N. Kok, Biomimetic Lipid Bilayers on Solid Surfaces: Models for Biological Interactions, Surface Innovations, 4(3): 141–157, DOI: 10.1680/jsuin.16.00008
7. S. Önder, A.C. Calikoglu-Koyuncu, G.T. Kose, K. Kazmanli, F.N. Kok*, M. Urgen, Effect of magnesium and osteoblast cell presence on hydroxyapatite formation on (Ti,Mg)N thin film coatings, JOMJ-The Journal of The Minerals, Metals & Materials Society (TMS) JOM, 69(7), 1195-1205, 2017
8. K. Bilir, M.-T. Weil, J. Lochead, F.N. Kok*, T. Werner, Construction of an oxygen detection based optic laccase biosensor for polyphenolic compound detection, Turkish Journal of Biology, 40: 1303-1310, 2016, doi:10.3906/biy-1602-40
9. F. Inci, U. Celik, B. Turken, H.Ö. Özer, F.N. Kok, Construction of P-glycoprotein incorporated tethered lipid bilayer membranes, Biochemistry and Biophysics Reports, 2, 115–122, 2015
10. H.Tezcan*, S. Oktug, F.N. Kok, Employing TDMA Protocol in Neural Nanonetworks in case of Neuron Specific Faults, IEEE Transactions on NanoBioscience, 14(6):572-580, 2015
11. S. Önder, A.C. Calikoglu-Koyuncu, K. Kazmanli, M. Urgen, G.T. Kose*, F.N. Kok, Behavior of Mammalian Cells on Magnesium Substituted Bare and Hydroxyapatite Deposited (Ti,Mg)N Coatings, New Biotechnology, 32(6), 747–755, 2015DOI: 10.1016/j.nbt.2014.11.006
12. G.Baysal*, S. Önder*, İ. Göcek, L. Trabzon, H. Kızıl, F. N. Kök and B.Karagüzel-Kayaoğlu, Design and Fabrication of a New Nonwoven-Textile Based Platform for Biosensor Construction, Sensors & Actuators: B. Chemical, 208, 475–484, 2015
13. G.Baysal*, S. Önder*, İ. Göcek, L. Trabzon, H. Kızıl, F. N. Kök and B.Karagüzel-Kayaoğlu, Microfluidic Device on a Nonwoven Fabric: A Potential Biosensor for Lactate Detection, Textile Research Journal, 84(16): 1729-1741, 2014
14. P.S. Gungor-Ozkerim, T. Balkan, G.T. Kose, A.S. Sarac, F.N.Kök, Incorporation of growth factor loaded microspheres into polymeric electrospun nanofibers for tissue engineering applications, Journal of Biomedical Materials Research: Part A (DOI: 10.1002/jbm.a.34857, 2013)
15. S.Önder, F.N.Kök, K.Kazmanlı, M.Ürgen, Magnesium Substituted Hydroxyapatite Formation on (Ti,Mg)N Coatings Produced by Cathodic Arc PVD Technique, Materials Science and Engineering C, 33, 4337-42, 2013
16. A.B. Ertan, P. Yılgor, B. Bayyurt, A.C. Çalıkoğlu, F.N. Kök, G.T. Kose, V. Hasirci, Effect of double growth factor release on cartilage tissue engineering, Journal of Tissue Engineering and Regenerative Medicine, 7:149-160, 2013
17. E. Tastan, S. Onder, F.N.Kök, Immobilization of Laccase on Polymer Grafted Polytetrafluoraelthylene Membranes for Biosensor Construction, Talanta, 84: 524-530, 2011
18. S. Onder, K. Kazmanlı, F.N.Kök, Alteration of PTFE Surface to Increase Its Blood Compatibility, J. Biomaterials Science: Polymer Ed, 22:1443–1457, 2011
19. E.-K. Sinner, U.Reuning, F.N.Kök, B.Saccà, L.Moroder, W.Knoll and D. Oesterhelt, Incorporation of integrins into artificial planar lipid membranes: characterization by plasmon-enhanced fluorescence spectroscopy, Analytical Biochemistry, 333(2): 216-224, 2004
20. F.N.Kök and V.Hasirci, Determination of binary pesticide mixtures by an acetylcholinesterase–choline oxidase biosensor, Biosensors and Bioelectronics, 19(7): 661-665, 2004
21. F.N.Kök, F.Bozoglu and V.Hasirci, Construction of an acetylcholinesterase-choline oxidase biosensor for aldicarb determination, Biosensors and Bioelectronics, 17(6-7): 531-539, 2002
22. F.N.Kök, F.Bozoglu and V.Hasirci, Immobilization of acetylcholinesterase and choline oxidase in/on pHEMA membrane for biosensor construction, Journal of Biomaterials Science Polymer Edition, 12(11): 1161-1176, 2001
23. F.N.Kök, R.M.Wilkins, R.B.Cain, M.Y.Arica, G.Alaeddinoglu and V.Hasirci, Controlled release of aldicarb from a lignin loaded ionotrophic hydrogel, Journal of Microencapsulation, 16(5): 613-623, 1999
24. F.N.Kök, M.Y.Arica, O.Gencer, K.Abak and V.Hasirci, Controlled Release of aldicarb from carboxymethylcellulose microspheres; in vitro and field applications, Pesticide Science, 55:1194-1202, 1999
25. F.N.Kök, M.Y.Arica, C.Halicigil, G.Alaeddinoglu and V.Hasirci, Biodegradation of aldicarb in a packed bed reactor by immobilized Methylosinus, Enzyme and Microbial Technology, 24:291-296, 1999
26. M.Y.Arica, M.Yigitoglu, M.Lale, F.N.Kök and V.Hasirci, Controlled release of aldicarb from carboxymethylcellulose microcapsules, Turkish Journal of Chemistry, 21(2): 100-104, 1997

Kitap Bölümleri ve Konferans Yayınları

1. F.N.Kök, “Bionanotechnology: Lessons from Nature for Better Material Properties” in Loww-Dimensional and Nanostructured Materials and Devices (Part of the series NanoScience and Technology, Eds: H.Ünlü, N.J.M. Horing, J. Dabowski, Springer Int. Pub. AG Switzerland, pp 535-553, 2016

2. F.N.Kök ve N.G. Karagüler, Proteinlerin Yapısı ve İşlevleri: Moleküler Biyoloji, ed. Mehmet Karataş, Nobel Yayın Dağıtım, pp 61-84, 201 2

3. F.N.Kök and V.Hasirci, Polyhydroxybutyrate and its copolymers: applications in the medical field, in: Tissue Engineering and Novel Delivery Systems, eds. M.J. Yaszemski, D.J.Trantolo, K-U. Lewandrowski, V. Hasirci, D.E. Altobelli and D.L. Wise, Marcel Dekker, Inc., pp 543-561, USA, 2004

4. F.N.Kök, F.Bozoglu and V.Hasirci, Construction of an acetylcholinesterase-choline oxidase biosensor for aldicarb determination, in Novel Processes and Control Technologies in the Food Industry, eds. F. Bozoglu, T. Deak, and B. Ray, IOS Press, NATO Science Series, pp 49-62, Nederlands, 2001

5. F.N.Kök, M.Y.Arica and V.Hasirci, In situ bioremediation of xenobiotics: immobilized biocatalysts in bioreactors, in: Bioremediation of Contaminated Soils, eds. D.L. Wise, D.J.Trantolo, E.J.Cichon, H.I.Inyang and U.Stottmeister, pp 133-150, Marcel Dekker, Inc., USA, 2000

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